G34, another connection between MYCN and a pediatric tumor.
نویسندگان
چکیده
Recurrent mutations in H3F3A at K27 and G34 are frequent in pediatric glioblastoma, but it is unclear how these mutations promote tumorigenesis. In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis.
منابع مشابه
IN THE SPOTLIGHT G34, Another Connection between MYCN and a Pediatric Tumor
Authors’ Affi liation: University of California San Francisco, San Francisco, California Corresponding Author: William A. Weiss, University of California San Francisco, 1450 Third Street, Room 277, MC 0520, San Francisco, CA 94158-9001. Phone: 415-502-1694; Fax: 415-476-0133; E-mail: [email protected] doi: 10.1158/2159-8290.CD-13-0126 ©2013 American Association for Cancer Research. IN THE SPOTL...
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Glioblastomas of children and young adults have a median survival of only 12-15months and are clinically and biologically distinct from histologically similar cancers in older adults1. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A2, occurring either at or close to key residues marked by methylation for regulation of transcription – K27 and G34...
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ورودعنوان ژورنال:
- Cancer discovery
دوره 3 5 شماره
صفحات -
تاریخ انتشار 2013